Invented by Mark W. Sleeman, Viktoria Gusarova, Andrew J. Murphy, Regeneron Pharmaceuticals Inc
The market for Anti-angptl3 antibody and its uses is growing rapidly as researchers and pharmaceutical companies are exploring its potential in treating various diseases. Anti-angptl3 antibody is a type of protein that is designed to target and inhibit the activity of angiopoietin-like protein 3 (angptl3), which is a protein that plays a crucial role in regulating lipid metabolism and glucose homeostasis.
The market for Anti-angptl3 antibody is primarily driven by the increasing prevalence of metabolic disorders such as dyslipidemia, hypercholesterolemia, and type 2 diabetes. These disorders are major risk factors for cardiovascular diseases, which are the leading cause of death worldwide. According to the World Health Organization, cardiovascular diseases account for approximately 17.9 million deaths each year, and this number is expected to rise in the coming years.
Anti-angptl3 antibody has shown promising results in preclinical and clinical studies for the treatment of dyslipidemia and hypercholesterolemia. In a phase 1 clinical trial, a single dose of anti-angptl3 antibody was found to reduce LDL cholesterol levels by up to 50% in healthy volunteers. Another phase 1 study showed that anti-angptl3 antibody reduced triglyceride levels by up to 70% in patients with hypertriglyceridemia.
Apart from its potential in treating metabolic disorders, anti-angptl3 antibody is also being explored for its role in treating other diseases such as non-alcoholic fatty liver disease (NAFLD), atherosclerosis, and certain types of cancers. In preclinical studies, anti-angptl3 antibody has been found to reduce liver fat accumulation and inflammation in mice with NAFLD. It has also been shown to inhibit the growth and metastasis of certain types of cancers such as breast cancer and lung cancer.
The market for Anti-angptl3 antibody is expected to grow significantly in the coming years as more research is conducted and more clinical trials are initiated. Several pharmaceutical companies such as Regeneron Pharmaceuticals, Amgen, and Ionis Pharmaceuticals are currently developing anti-angptl3 antibody-based therapies for various diseases. In 2019, Regeneron Pharmaceuticals received FDA approval for its anti-angptl3 antibody-based therapy, Evkeeza, for the treatment of homozygous familial hypercholesterolemia (HoFH).
In conclusion, the market for Anti-angptl3 antibody and its uses is growing rapidly as researchers and pharmaceutical companies are exploring its potential in treating various diseases. With its promising results in preclinical and clinical studies, anti-angptl3 antibody has the potential to become a game-changer in the treatment of metabolic disorders, NAFLD, atherosclerosis, and certain types of cancers. As more research is conducted and more clinical trials are initiated, the market for Anti-angptl3 antibody is expected to grow significantly in the coming years.
The Regeneron Pharmaceuticals Inc invention works as follows
A fully-human antibody or antigen binding fragment of a full-human antibody that specifically binds, inhibits or interferes at least one activity human angiopoietinlike protein 3(hANGPTL3)” is provided. The human anti-hANGPTL3 antibodies are useful in treating diseases or disorders associated with ANGPTL3, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. The anti-hANGPTL3 antibody can also be given to a patient to treat or prevent diseases and disorders where abnormal lipid metabolism may be a factor. These diseases or disorders can include cardiovascular diseases such as atherosclerosis, coronary artery disease, acute pancreatitis, nonalcoholic steatohepatitis(NASH), diabetes and obesity.
Background for Anti-angptl3 antibody and its uses
Preparation Human Antibodies
Epitope Mapping & Related Technologies
Therapeutic Administrations and Formulations
Antibodies for Diagnostic Uses
Example 1 : Generation of Human Antibodies against Human ANGPTL3
Example 2. Variable Gene Utilization Analysis
Example 3. “Example 3.
Example 4. Biacore Cross-Competition Study of Anti-ANGPTL3 Antibodies
Example 5. “Example 5.
Example 6. “Example 6.
Example 7.1. Effect of Anti-ANGPTL3 Antibody in Vivo on Serum Lipids
Example 7.2. Effects of Anti-ANGPTL3 Antibodies in Vivo on Serum Lipid Concentrations
Example 8. “In Vivo Effects of H4H1276S On Serum Lipid levels in Hyperlipidemic ApoE Mice” Mice
Example 9. “In Vivo Effect of the H4H1276S in Hyperlipidemic Mouse Circulating LipidsClick here
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