Invented by Giuseppe Ciaramella, Eric Yi-Chun Huang, Kapil Bahl, Tal Zaks, Sunny Himansu, Sayda Mahgoub Elbashir, ModernaTx Inc

The Market for Infectious Disease Vaccines: A Growing Demand for Global Health Infectious diseases have been a persistent threat to human health throughout history. From smallpox to polio, these diseases have caused widespread illness, death, and economic disruption. However, with the advent of vaccines, we have made significant progress in preventing and controlling infectious diseases. Vaccines have been instrumental in eradicating smallpox, reducing the incidence of polio, and preventing countless cases of measles, mumps, and rubella. The market for infectious disease vaccines has seen substantial growth in recent years, driven by a combination of factors. Firstly, the increasing global population and urbanization have led to a higher risk of disease transmission. As people live in closer proximity to each other, infectious diseases can spread more easily. This has created a greater demand for vaccines to protect individuals and communities from these diseases. Secondly, the emergence of new infectious diseases and the reemergence of old ones have highlighted the need for effective vaccines. Diseases such as Ebola, Zika, and COVID-19 have demonstrated the devastating impact that infectious diseases can have on public health and the global economy. As a result, there is a growing recognition of the importance of investing in vaccine research and development to prevent future outbreaks. Furthermore, advancements in technology and scientific understanding have accelerated the development of new vaccines. Traditional vaccine production methods, such as using weakened or inactivated forms of the pathogen, have been complemented by newer approaches like recombinant DNA technology and mRNA vaccines. These innovations have not only improved the efficacy and safety of vaccines but also allowed for faster development and production. The market for infectious disease vaccines is not limited to developed countries. In fact, many low- and middle-income countries face a higher burden of infectious diseases and have a greater need for vaccines. Organizations like Gavi, the Vaccine Alliance, have played a crucial role in expanding access to vaccines in these regions. Gavi has helped to increase vaccine coverage and reduce the cost of vaccines, making them more accessible to those who need them the most. The COVID-19 pandemic has further underscored the importance of vaccines in controlling infectious diseases. The rapid development and deployment of COVID-19 vaccines have demonstrated the power of vaccines in saving lives and reopening economies. This has led to increased public awareness and acceptance of vaccines, which bodes well for the future market for infectious disease vaccines. However, challenges remain in ensuring equitable access to vaccines. Vaccine distribution and supply chain issues, as well as vaccine hesitancy, can hinder the successful implementation of vaccination programs. Addressing these challenges will require collaboration between governments, international organizations, and the private sector to ensure that vaccines reach all corners of the world. In conclusion, the market for infectious disease vaccines is experiencing significant growth due to the increasing global population, the emergence of new diseases, and advancements in vaccine technology. The COVID-19 pandemic has further highlighted the importance of vaccines in preventing and controlling infectious diseases. As we continue to invest in vaccine research and development, it is crucial to ensure equitable access to vaccines for all, regardless of their geographical location or socioeconomic status. By doing so, we can protect global health and reduce the burden of infectious diseases on society.

The ModernaTx Inc invention works as follows

Nucleic acid vaccines are covered by certain aspects of the disclosure. The vaccines contain one or several RNA polynucleotides with an open-reading frame that encodes one or multiple Chikungunya virus antigens (or antigens), as well as one or many Zika virus antigens and one or many Dengue virus antigens. The methods for preparing and utilizing such vaccines are described.

Background for Infectious disease vaccines


Nucleic Acids/Polynucleotides

Antigens/Antigenic Polypeptides

Multiprotein and Multicomponent Vaccines

Signal Peptides

Chemical Modifications

Methods of Treatment.

Broad Spectrum Vaccines

Therapeutic Compositions and Prophylactic Compositions

Stabilizing Elements

Nanoparticle Formulations

Modes for Vaccine Administration”.

RNA Vaccine Formulations & Methods of Usage


Example 1 : Manufacturing of Polynucleotides

Example 2 : Chimeric Polynucleotide


Synthetic Route

Example 3 : PCR for the Production of cDNA

Example 4: In Vitro Transcription (IVT)

4 RNase Inhibitor, 20 U

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