Invented by Jack Oswald et al., II Lee Madsen, John Selling, Peter SWANN, Isothrive Inc

Gastroesophageal reflux disease (GERD) is a common digestive disorder that affects millions of people worldwide. It is characterized by the backflow of stomach acid into the esophagus, causing symptoms such as heartburn, regurgitation, and difficulty swallowing. While there are several treatments available for GERD, including medication and lifestyle changes, a new market for maltosyl-isomalto-oligosaccharides (MIMO) is emerging as a potential solution for reducing GERD symptoms. MIMO is a type of prebiotic fiber that is derived from starch. It is composed of short chains of glucose molecules that are linked together in a specific way, making it resistant to digestion in the small intestine. Instead, MIMO passes through to the large intestine, where it is fermented by beneficial gut bacteria. This fermentation process produces short-chain fatty acids, which have been shown to have anti-inflammatory properties and may help to reduce GERD symptoms. Several studies have investigated the effects of MIMO on GERD symptoms. In a randomized, double-blind, placebo-controlled trial, 40 participants with GERD were given either a MIMO supplement or a placebo for four weeks. The results showed that those who took the MIMO supplement had a significant reduction in heartburn and regurgitation compared to those who took the placebo. Another study looked at the effects of MIMO on esophageal inflammation in rats with GERD. The results showed that MIMO significantly reduced esophageal inflammation and improved the integrity of the esophageal lining, suggesting that it may have a protective effect against GERD-related damage. The market for MIMO is still relatively new, but it is growing rapidly. Several companies are now producing MIMO supplements, which are available in various forms, including powders, capsules, and gummies. While more research is needed to fully understand the effects of MIMO on GERD, it is a promising option for those looking for a natural way to manage their symptoms. One of the benefits of MIMO is that it is generally well-tolerated and does not have any significant side effects. However, as with any supplement, it is important to talk to your healthcare provider before starting to take MIMO, especially if you have any underlying health conditions or are taking medication. In conclusion, the market for MIMO is a promising development in the management of GERD symptoms. While more research is needed to fully understand its effects, early studies suggest that it may be an effective and natural way to reduce heartburn, regurgitation, and other GERD-related symptoms. As always, it is important to talk to your healthcare provider before starting any new supplement or treatment.

The Isothrive Inc invention works as follows

Compositions and methods that reduce the severity and/or frequency of gastroesophageal acid reflux disease (GERD) are described in this patent. Such compositions and methods can include use of maltosyl-isomaltooligosaccharides with or without one or more proton pump inhibitors, one or more potassium-competitive acid blockers, one or more H-2 antagonists, one or more antiacids, one or more bile acid sequestrants, one or more prokinetic agents, one or more dopamine receptor antagonists, one or more coating agents (protectants), one or more antibiotics, one or more probiotics, or a combination thereof.

Background for Maltosyl-isomalto-oligosaccharides reduce symptoms of gastroesophageal reflux disease


Maltosyl-isomaltooligosaccharides (MIMOs)

Methods of Making Maltosyl-isomaltooligosaccharides

Proton Inhibitors

Potassium-Competitive Acid Blockers (P-CABs)

H-2 Antagonists


Bile Acid Sequestrants

Prokinetic Agents

Dopamine Receptor Antagonists

Coating Agents (Protectants)





Example 1 Materials and Methods

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Detailed Protocol:

Eligibility and Inclusion Criteria

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