Invented by Rahul Dev Jayant, Madhavan NAIR, Florida International University FIU
The Market For Materials For Sustained Release Active Compounds
The market for Materials for Sustained Release Active Compounds is anticipated to experience strong growth over the forecast period. This growth can be attributed to increasing patent expirations, increased R&D initiatives and an increasing demand for pediatric and geriatric dosage forms.
Excipients have been developed to increase drug bioavailability and extend its action. These include polymers, nanocarriers and formulation systems that blend different organic excipient classes together for pharmaceutical forms with several advantages.
Biopolymeric materials are a type of polymer commonly used in various applications. They typically derive from naturally occurring resources like sugars and proteins, though some can also be synthetically engineered with desired properties.
One major advantage to using these materials is that they are mostly biodegradable, helping reduce environmental pollution caused by plastic products. Furthermore, it decreases our reliance on non-renewable fossil fuels which are becoming a bigger risk to the planet.
Another reason why many are choosing these materials is that they can easily be recycled or composted when no longer required. This reduces landfill garbage, helping reduce air pollution.
Biopolymeric materials are currently employed in various industries, such as the medical and food sectors. These include organic and inorganic matrices for tissue engineering, scaffolds for cell encapsulation and distribution, and vascular grafts for soft-tissue repair.
Biopolymers have seen a meteoric rise in recent years as an effective drug delivery system due to their versatility, abrasion resistance, biocompatibility and biodegradability. They can be employed for various purposes like implantable devices for blood, vascular or nerve transport as well as intraocular lenses, surgical implants and ophthalmic surgery.
Furthermore, biopolymers can be combined with various nanoparticles that impart beneficial physical, chemical, and optical characteristics. Furthermore, they may incorporate peptide-based molecules that enhance cell interactions and offer an appropriate platform for cellular and tissue functions.
These biopolymeric materials are highly versatile, abrasion resistant, and biocompatible. They can be utilized in a range of soft-tissue repair applications such as implantable devices for blood, vascular, nerve transport, intraocular lenses, surgical implants, and ophthalmic surgeries.
The use of these materials is becoming increasingly commonplace in the medical industry, as they are highly biocompatible and versatile enough for various uses. Furthermore, these compounds serve as a great alternative to traditional polymers used for these applications and have been demonstrated to be highly effective at controlling drug release rates.
Biodegradable materials refer to polymers derived from renewable sources that can be decomposed in a controlled environment by micro-organisms. This type of material finds application across many industries and for various purposes.
The market for materials that break down after use is expanding due to their reusability, reprocessability, recycling and composting options or regenerating biomass at the end of their lifecycle. This reduces waste production and carbon footprint – an increasingly important consideration for pharmaceutical companies looking to minimize their global impact.
Biodegradable plastics are increasingly being made from plant-based materials like corn starch and potato starch. When exposed to air, moisture, or microbes, these biodegradable plastics break down into water, organic compounds and minerals.
These materials can also be combined with other polymers to form a blend that incorporates the properties of both types. This is an effective way to produce materials which are both biodegradable and long-lasting.
This type of material has many applications, such as electronics and robotics. It also can be utilized to create both reusable and disposable clothing and products.
Biodegradable plastics are available, but the best ones will break down within months or years rather than decades or centuries. This is especially true of plastics made from renewable resources like plant-based resins or hydrocarbons that break down quickly.
These materials are an excellent way to reduce our carbon footprint, but they have one major drawback: They’re expensive to manufacture. This means manufacturers must find ways to encourage consumers to use them.
Another drawback of synthetic materials is their slow decomposition rate; thus, they cannot be used in electronics or robotics applications where devices must be returned to nature after use. This poses a problem for businesses looking to recycle their waste streams.
Biodegradable polymers such as polylactic acid (PLA), ethylene glycol methacrylate and caprolactone-butylene succinate are the most popular choices. These versatile materials can be molded into various shapes and sizes to make products like bags or toys.
Biodegradable Matrix Materials
The market for Materials for Sustained Release Active Compounds has an immense growth potential due to the rising incidence of diseases, the expanding population, and growing demands for sustainable crop protection. By using nature-derived biodegradable materials as crop protection solutions, one can reduce pesticide application without harming the environment while increasing agrochemical efficiency.
Biodegradable matrix materials are widely used, including starch, natural fiber polymer composites, cellulose nanofibers, polylactic acid (PLA), and silica gel. The degradability of a matrix material depends on its morphology, structure, chemical treatments applied, as well as its molecular weight.
Starch is an important source of biodegradable polymers and has many applications such as medical implants, textiles and food containers. Due to its strength and stiffness, starch makes for great reinforcement in polymer matrix composites.
Starch has poor tensile properties and water sensitivity, making it unsuitable for many surgical uses11. Therefore, modifications to starch or the use of other biodegradable polymers with enhanced mechanical properties must be made in order to improve their suitability for such tasks.
Different biodegradable polymers and their composites possess various mechanical, thermal, and electrical properties. PLA (polylactic acid) boasts high tensile strength, excellent heat resistance and thermostability – making it a perfect option for biodegradable medical devices.
Polyethylene terephthalate (PET) on the other hand, has low tensile strength and poor heat and moisture resistance. PET is an environmentally friendly and recyclable polymer that degrades into non-toxic waste when discarded.
Biodegradable matrices are created through polymerization of alkoxysilanes such as Si(OR)4. These alkoxysilanes are synthesized in an aqueous solution and form an amorphous gel at the nanoscale. The amount of OH groups on the surface of a matrix affects its biodegradation rate, as does its specific surface area.
Biodegradable polymers, commonly used in plastic manufacturing, can be sourced from renewable sources such as corn, potato and rice. These biodegradable plastics provide an eco-friendly alternative to traditional synthetic plastics with lower carbon footprints compared to their fossil-based counterparts10.
Biodegradable polymers are widely used in medical implants and textiles. Their biodegradability is an integral feature of medical devices, helping to minimize environmental damage caused by waste disposal processes.
Biodegradable microspheres have gained increasing attention for their potential to deliver drugs through various routes. Selecting the appropriate biodegradable polymers and employing an effective preparation technique are critical elements in achieving successful drug delivery.
Poly(lactic acid) (PLA) and poly(lactic/glycolic acid) copolymer (PLGA) are two of the most widely used biodegradable polymers used in biopharmaceuticals, which can be synthesized via different chemical synthesis methods like electrospray, polycondensation or adsorption. They exhibit excellent compatibility with most drug compounds, possess excellent biocompatibility and come in various shapes, sizes and surface modifications.
PLGA microspheres can be manufactured through various encapsulation and coating methods, the most popular being emulsification. This easy-to-follow procedure produces microspheres with exceptional sphericity and uniformity; furthermore, you can control the size and shape of your finished product by altering water/polymer ratios during encapsulation – even microspheres with controlled release rates!
The emulsion method is ideal for the encapsulation of temperature-sensitive drugs. The preparation process is straightforward and permits the encapsulation of various drug molecules, such as protein or peptide drugs. It has many applications, such as binding biological proteins to ligands used in immunoprecipitation experiments.
Recently, PLGA was utilized to formulate microspheres containing sustained release depot formulations of leuprorelin acetate and thyrotropin-releasing hormone (TRH), as well as rasagiline mesylate (RM), an effective antioxidant, in rat models of Parkinson disease (PD). These RM-encapsulated microspheres were administered intravenously every two weeks for controlled release of RM.
This approach has been successfully applied to various Parkinson’s disease (PD) model animals. The combination of an innovative injection technique, the control over release rate and pharmacological effect, as well as its safe administration make this innovative drug delivery system an attractive option for PD therapy (Fernandez et al., 2012).
Another potential use for PLGA microspheres is in eye disease management. Studies have demonstrated they are successful at treating various vitreoretinal diseases such as age-related macular degeneration, diabetic retinopathy, glaucoma and cataracts. Furthermore, these microspheres are easy to inject with long-lasting sustained release of drugs which increases bioavailability while decreasing potential side effects.
The Florida International University FIU invention works as followsThe subject invention provides nanoparticle delivery systems and methods for making and using them. The present invention is a nanoparticle drug delivery method that includes a magnetic nanoparticle (MNP), encapsulated in a bilayer coating that contains a layer with drug molecules and a polymer. Another aspect of the nanoparticle delivery system is the systemic administration and localization of the nanoparticles in the targeted treatment area. The nanoparticle drug delivery method can be used to treat HIV/AIDS.
Background for Materials for sustained release active compounds
Conditions to Be Treated
Treatment for Viral Infections (Including HIV-AIDS)
Localization to Target Area.
Routes of Administration.
Layer-by?Layer Coatings on MNPs
Activation and Evaluation of In Vitro Antiviral Effectiveness of Nanoformulation
Time Kinetics, Drug-Binding Isotherm for MNPs
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