Invented by Kelly M. HARKINS KINCAID, Joshua D. KAPP, Christopher J. TROLL, Claret Bioscience LLC

The market for methods of analyzing nucleic acids has experienced significant growth in recent years. Nucleic acids, such as DNA and RNA, play a crucial role in various biological processes, making their analysis essential for a wide range of applications, including medical diagnostics, drug development, agriculture, and forensic sciences. Advancements in technology have revolutionized the field of nucleic acid analysis, enabling researchers to study and understand these molecules with unprecedented precision and speed. Traditional methods, such as polymerase chain reaction (PCR) and gel electrophoresis, have been widely used for several decades. However, these techniques have limitations in terms of sensitivity, throughput, and cost-effectiveness. The emergence of next-generation sequencing (NGS) technologies has transformed the landscape of nucleic acid analysis. NGS allows for the simultaneous sequencing of millions of DNA fragments, providing researchers with a vast amount of genetic information in a single experiment. This has revolutionized fields like genomics, transcriptomics, and epigenomics, enabling researchers to study the entire genome, transcriptome, or epigenome of an organism in a comprehensive manner. The market for NGS technologies has witnessed exponential growth, driven by the increasing demand for personalized medicine, genetic research, and agricultural genomics. Companies like Illumina, Thermo Fisher Scientific, and Pacific Biosciences have dominated the market, offering a range of NGS platforms with varying capabilities and costs. These platforms have become more accessible and affordable over time, making NGS a standard tool in many research laboratories and clinical settings. Apart from NGS, other methods of nucleic acid analysis have also gained traction in the market. For instance, quantitative polymerase chain reaction (qPCR) remains a popular technique for gene expression analysis and pathogen detection due to its high sensitivity and specificity. Digital PCR (dPCR) has emerged as a promising alternative to qPCR, allowing for absolute quantification of nucleic acids without the need for standard curves. Furthermore, techniques like microarrays and RNA sequencing (RNA-seq) have become valuable tools for studying gene expression patterns and identifying potential biomarkers. These methods enable researchers to analyze the entire transcriptome of an organism, providing insights into gene regulation, disease mechanisms, and drug responses. The market for nucleic acid analysis methods is expected to continue growing in the coming years. The increasing adoption of NGS technologies in clinical diagnostics, particularly in oncology, is likely to drive market growth. Additionally, the growing interest in precision medicine and the development of targeted therapies will fuel the demand for nucleic acid analysis tools. Moreover, the rise of synthetic biology and gene editing technologies, such as CRISPR-Cas9, will further boost the market. These technologies rely on accurate and efficient nucleic acid analysis methods to design and validate genetic modifications. In conclusion, the market for methods of analyzing nucleic acids has experienced significant growth due to advancements in technology and increasing applications in various fields. NGS technologies, along with other methods like qPCR, dPCR, microarrays, and RNA-seq, have revolutionized the study of nucleic acids, enabling researchers to gain a deeper understanding of genetic information. As the demand for personalized medicine, genetic research, and targeted therapies continues to rise, the market for nucleic acid analysis methods is expected to expand further in the future.

The Claret Bioscience LLC invention works as follows

The technology is related to compositions and methods for analyzing a nucleic acid. The technology is related to some methods and compositions used for the preparation of a nucleic library. The technology is related to some methods and compositions that are used for the analysis of ends of nucleic acids fragments.

Background for Methods of analyzing nucleic acids

Nucleic Acid Ends

Oligonucleotides

Y-Oligonucleotides

Hairpins

Modified Nucleotides

Phosphorylation & Dephosphorylation

Hybridization & Ligation

Cleavage

Nick Seal & Fill-in

Exonuclease Treatment

Second Pool of Oligonucleotides

Samples

Nucleic Acid

Enriching Nucleic Acids

Length-Based Separation

Nucleic Acid Library

Nucleic acid Sequencing

Mapping Reads

Sequence Read Quantification

Assays

Classifications of Uses

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