Invented by Scott LOUGHHEAD, Leeann Talarico, Alfonso Vicente-Suarez, Matt Booty, Howard Bernstein, Katarina BLAGOVIC, Armon R. Sharei, Kelan HLAVATY, Melissa Myint, SQZ Biotechnologies Co

Human papillomavirus (HPV) is a common sexually transmitted infection that affects both men and women. While most HPV infections go away on their own, some can lead to serious health problems such as genital warts and various types of cancer, including cervical, anal, and throat cancer. As a result, there is a growing market for methods of treating HPV-associated diseases. One of the most effective ways to prevent HPV-associated diseases is through vaccination. The HPV vaccine is recommended for both boys and girls between the ages of 9 and 14, and can also be given to young adults up to age 26. The vaccine is highly effective at preventing the types of HPV that cause most cases of cervical cancer, as well as other HPV-related cancers and genital warts. For those who have already been infected with HPV, there are a variety of treatment options available. For example, genital warts can be treated with topical medications or removed through various procedures such as cryotherapy, laser therapy, or surgical excision. In addition, precancerous cells in the cervix can be removed through procedures such as loop electrosurgical excision procedure (LEEP) or cone biopsy. In recent years, there has also been a growing interest in using immunotherapy to treat HPV-associated cancers. Immunotherapy works by stimulating the body’s immune system to attack cancer cells. One type of immunotherapy that has shown promise in treating HPV-related cancers is called checkpoint inhibitors. These drugs block certain proteins on cancer cells that prevent the immune system from attacking them, allowing the body to mount a stronger immune response against the cancer. Another area of research is the development of therapeutic vaccines for HPV-associated cancers. These vaccines work by stimulating the immune system to recognize and attack cancer cells. While there are currently no FDA-approved therapeutic vaccines for HPV-associated cancers, several are in clinical trials and showing promising results. Overall, the market for methods of treating HPV-associated diseases is expected to continue to grow as awareness of the link between HPV and cancer increases. While vaccination remains the most effective way to prevent HPV-related cancers, there are a variety of treatment options available for those who have already been infected. As research in immunotherapy and therapeutic vaccines continues to advance, there is hope that even more effective treatments will become available in the future.

The SQZ Biotechnologies Co invention works as follows

The present application provides modified immune cell that contains an HPV antigen, an adjuvant and methods for manufacturing them, as well as methods for using these modified immune cells to treat an HPV associated disease, prevent an HPV associated disease and/or modulate an immune response within an individual who has an HPV related disease.

Background for Methods of treating hpv associated diseases

Definitions

Microfluidic systems and components thereof

Microfluidic channels to provide cell-deforming constrictions

Surface with Pores that Provide Cell Deforming Constrictions

Cell Perturbations

Delivery Parameters

Antigens & Adjuvants for Enhancing an Immune Response”.

Compositions

PBMC Composition

Conditioning PBMCs

Applications

Systems and kits

EXEMPLARY EMBODIMENTS

EXAMPLES

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