Invented by Bart De Goeij, Edward N. Van Den Brink, Simone De Haij, Thilo Riedl, Rene Hoet, D.M.Sc. Ole BAADSGAARD, David Satijn, Jan van de Winkel, Paul Parren, Genmab AS

The market for Monoclonal Antibodies (mAbs) against the HER2 epitope has been rapidly growing in recent years. HER2, also known as human epidermal growth factor receptor 2, is a protein that plays a crucial role in cell growth and division. However, when HER2 is overexpressed in certain types of cancer, such as breast and gastric cancer, it can lead to uncontrolled cell growth and tumor formation. Monoclonal antibodies are laboratory-produced molecules that can mimic the immune system’s ability to fight off harmful pathogens or abnormal cells. In the case of HER2-positive cancers, mAbs against the HER2 epitope can specifically target and bind to the HER2 protein, inhibiting its activity and preventing the growth of cancer cells. The market for mAbs against the HER2 epitope has witnessed significant growth due to several factors. Firstly, the prevalence of HER2-positive cancers has been increasing globally. Breast cancer, in particular, is one of the most common cancers among women, and approximately 20-30% of breast cancer cases are HER2-positive. This high prevalence has created a substantial demand for targeted therapies, such as mAbs against the HER2 epitope. Secondly, the effectiveness of mAbs against the HER2 epitope has been well-documented. Clinical trials and real-world evidence have shown that these therapies can significantly improve patient outcomes, including overall survival and progression-free survival rates. As a result, healthcare providers and patients are increasingly opting for these targeted therapies as part of their treatment regimens. Furthermore, advancements in biotechnology and genetic engineering have facilitated the development and production of mAbs against the HER2 epitope. These therapies can now be manufactured at a large scale, ensuring a steady supply to meet the growing demand. Additionally, the introduction of biosimilars, which are highly similar versions of existing mAbs, has increased competition in the market, leading to lower prices and improved accessibility for patients. The market for mAbs against the HER2 epitope is highly competitive, with several pharmaceutical companies actively involved in research and development. Some of the key players in this market include Roche/Genentech, Pfizer, Novartis, and AstraZeneca. These companies are continuously investing in clinical trials and expanding their product portfolios to cater to the diverse needs of patients with HER2-positive cancers. In conclusion, the market for mAbs against the HER2 epitope is witnessing significant growth due to the increasing prevalence of HER2-positive cancers and the proven efficacy of these targeted therapies. Advancements in biotechnology and the introduction of biosimilars have further fueled this growth. As research continues to uncover new insights into the HER2 pathway and its role in cancer, the market for mAbs against the HER2 epitope is expected to expand even further, offering hope for improved treatment outcomes for patients with HER2-positive cancers.

The Genmab AS invention works as follows

Isolated monoclonal antibody which binds to human epidermal-growth factor receptor 2″ (HER2) and related antibodies-based molecules and compositions are disclosed. The antibodies, as well as therapeutic and diagnostic methods involving the antibodies, are disclosed.

Background for Monoclonal antibody against her2 epitope


Further Aspects and Embodiments of the Invention

Antibody Formats


Bispecific Antibodies

Nucleic Acid Sequences: Vectors, Host Cells and Other Related Topics




Diagnostic Uses

Anti-Idiotypic Antibodies


Example 1: Expression Constructs for HER2

Example 2?” Expression Constructs for Pertuzumab C1 and F5

Example 3: Transient expression in HEK-293 and CHO cells

Example 4.?Stable Polyclonal Pool expression in NS0″.

Example 5?Purification His-Tagged HER2

Example 6? Immunization procedure of transgenic mice

Example 7?Homogeneous Antigen Specific Screening Assay

Example 8?HuMab Hybridoma Generation

Example 9. Mass Spectrometry of purified Antibodies

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