Invented by Mark Smith, Stephen Caddick, James Baker, Vijay Chudasama, UCL Business Ltd

The market for reversible covalent bonding of functional molecules is rapidly expanding, driven by the increasing demand for advanced materials and technologies in various industries. This innovative approach to bonding offers numerous benefits and has the potential to revolutionize the way we design and manufacture products. Reversible covalent bonding involves the formation of strong chemical bonds between functional molecules that can be easily broken and reformed under specific conditions. This allows for the creation of dynamic materials with tunable properties, such as self-healing materials, shape-memory polymers, and stimuli-responsive coatings. One of the key advantages of reversible covalent bonding is its ability to enable self-healing materials. These materials have the remarkable ability to repair themselves when damaged, extending their lifespan and reducing the need for frequent replacements. This is particularly valuable in industries such as automotive, aerospace, and construction, where durability and longevity are crucial. Shape-memory polymers are another exciting application of reversible covalent bonding. These materials can be deformed into a temporary shape and then triggered to revert back to their original shape when exposed to specific stimuli, such as heat or light. This property opens up new possibilities in fields like biomedical engineering, where shape-memory polymers can be used in minimally invasive surgeries or drug delivery systems. Stimuli-responsive coatings are yet another area where reversible covalent bonding is making a significant impact. These coatings can change their properties in response to external stimuli, such as temperature, pH, or light. This versatility allows for the development of smart coatings that can adapt to different environmental conditions, offering enhanced protection, improved energy efficiency, and even self-cleaning capabilities. The market for reversible covalent bonding is expected to witness substantial growth in the coming years. The demand for advanced materials with unique properties is increasing across various industries, including healthcare, electronics, energy, and consumer goods. Additionally, the growing focus on sustainability and environmental consciousness is driving the need for materials that can be recycled or repaired, further fueling the demand for reversible covalent bonding technologies. Several companies and research institutions are actively involved in developing and commercializing reversible covalent bonding technologies. They are investing in research and development to expand the range of functional molecules that can undergo reversible bonding and optimize the conditions for bond formation and breakage. Additionally, efforts are being made to scale up production processes and reduce costs to make these technologies more accessible to a wider range of industries. In conclusion, the market for reversible covalent bonding of functional molecules is poised for significant growth and innovation. The ability to create dynamic materials with tunable properties opens up new possibilities in various industries, from self-healing materials to shape-memory polymers and stimuli-responsive coatings. As research and development efforts continue to advance, we can expect to see more applications and commercialization of these technologies, revolutionizing the way we design and manufacture products in the future.

The UCL Business Ltd invention works as follows

The present invention is concerned with the use of a compound that contains a moiety from formula (I) to link a compound R1?H, which comprises a functional moiety F1 to a functional moiety F2nnwherein R1, F1, and F2 as defined are used. The present invention provides also related processes and products. The present invention can be used to create functional conjugate compounds and more specifically conjugates where at least one constituent molecule carries a Thiol group.

Background for Reversible covalent bonding of functional molecules

The present invention relates to (1) the use of a compound having a moiety (I) in a reagent used for linking a formula R1?H compound which contains a first functional moiety F1 and a second functional molecule F2


The present invention provides also (2) a method for producing a conjugate which comprises

The present invention provides (3) a method for producing a conjugate. This process includes reacting a formula R1?H compound with a formula I moiety and at least one formula F2 moiety linked thereto.

Still Further, the present invention provides (4) A process which includes

(i), providing a compound containing a moiety (II);

(ii), cleaving of the bond between group R1 with the carbon atom in the 2-position on the moiety (II);


As a skilled chemist will see, these uses and processes can be linked together by the fact that it’s advantageous to add an electrophilic group to the C-C double bond in a well-known dicarbonyl ethene reagent. Many of the intermediates, products and uses involved in these processes and uses are considered novel. “The present invention also provides embodiments (5)-(9).

The present invention (5) provides a compound with formula (IIa).


Also, the present invention provides (6) a chemical compound of formula IIb


The present invention also provides (7) a chemical compound of formula II


Still Further, the Present Invention Provides (8) A Compound of Formula (IIIa)”.


The present invention (9) provides a compound with formula (IVa), or (IVb).


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