Cannabis Patents and Trademarks – John Feder, Chandra Ramanathan, Gabriel Mintier, Angela Cacace, Lauren Barber, Bristol Myers Squibb Co

Abstract for “Polynucleotide encoding a novel G-protein coupled human receptor, HGPRBMY26”

“The invention provides novel polynucleotides encoding HGPRBMY26 peptides, fragments, and homologues. Vectors, host cells and antibodies are also provided. Further, the invention relates to diagnostic methods and therapeutic methods for using these novel HGPRBMY26 peptides in order to diagnose, treat, and/or prevent various diseases and/or disorders that are related to these polypeptides. Screening methods are used to identify agonists or antagonists of polynucleotides, polypeptides and other compounds of the invention.

Background for “Polynucleotide encoding a novel G-protein coupled human receptor, HGPRBMY26”

“Polynucleotides & Polypeptides of the Invention.”

“EXAMPLES”

“Description of the Prefer Embodiments”

“Example 1?Bioinformatics Analysis”

“Example 2?” Cloning of the Novel Human Human HGPRBMY26 G Protein Coupled Receptor

“Example 3?”Expression Profiling the Novel Human Human HGPRBMY26 Protein”

“Example 4:Method for Assessing the Expression Profile Of The Novel HGPRBMY26 Proteins of the Present Invention Using Expanded mRNATissue and Cell Sources”

“Example 5?”Functional Characterization for the Novel Human GPCR (HGPRBMY26)

“Example 6: Method of Assessing the Physiological Functional of the HGPRBMY26 polypeptide at the Cellular Level.”

“Example 7:Method for Assessing the Physiological Functional of the HGPRBMY26 Polypeptides In Xenopus Oocytes.”

“Example 8: Method of Assessing the Physiological Functional of the HGPRBMY26 polypeptides Using microphysiometric Assays.”

“Example 9: Method of Assessing the Physiological Functionality of the HGPRBMY26 Polypeptides Using Calc and Camp Functional Assays.”

“Example 11” Method of Screening, In Vitro Compounds That Bind to the HGPRBMY26Polypeptide

“Example 12” Method for Identifying a Potential Ligand for the HGCRBMY11Polypeptide

“Example 13” Method of Identifying Compounds That Interfere With HGPRBMY26 Polypeptide/Cellular Products Interaction

“Example 14”: Isolation of a Specific Clone From the Deposited Sample

“Example 15?”Chromosomal Mapping the Polynucleotides

“Example 16?” Bacterial Expression of a Protein

“Example 17: Purification of a Polypeptide From an Inclusion Body”

“Example 18?” Cloning and Expression of a Baculovirus Polypeptide in an Expression System

“Example 19″Expression of a Polypeptide In Mammalian Cells

“Example 20?Protein Fusions”

“Example 21: Production of an Antibody from a Polypeptide.”

“Example 22” Method of Creating C- and N-terminal Deletion Mutants Corresponding with the HGPRBMY26 polypeptide of the Present Invention

“Example 23: Method of Enhancing the Biological Activity/Functional Characteristics Of Invention Through Molecular Evolution.”

“Example 24: Method of Determining Alterations In a Gene Corresponding To a Polynucleotide.”

“Example 25” Method of Detecting Abnormally High Levels of a Polypeptide In a Biological Sample

“Example 26?Formulation”

“Example 27” Method of Treating Reduced Levels of the Polypeptide

“Example 28” Method of Treating Increased Levels Of The Polypeptide

“Example 29” Method of Treatment with Gene Therapy-Ex Vivo

“”

“Example 31” Method of Treatment using Gene Therapy?In Vivo

“Example 32?Transgenic Animals”

“Example 33?Knock-Out Animals”

“Example 34: Production of an Antibody”

“Example 35: Identification and Cloning VH and L domains of Antibodies directed against the HGPRBMY26 polypeptide”

“Example 36?Diabetic Mouse and Glucocorticoid-Impaired Wound Healing Models”

Summary for “Polynucleotide encoding a novel G-protein coupled human receptor, HGPRBMY26”

“Polynucleotides & Polypeptides of the Invention.”

“EXAMPLES”

“Description of the Prefer Embodiments”

“Example 1?Bioinformatics Analysis”

“Example 2?” Cloning of the Novel Human Human HGPRBMY26 G Protein Coupled Receptor

“Example 3?”Expression Profiling the Novel Human Human HGPRBMY26 Protein”

“Example 4:Method for Assessing the Expression Profile Of The Novel HGPRBMY26 Proteins of the Present Invention Using Expanded mRNATissue and Cell Sources”

“Example 5?”Functional Characterization for the Novel Human GPCR (HGPRBMY26)

“Example 6: Method of Assessing the Physiological Functional of the HGPRBMY26 polypeptide at the Cellular Level.”

“Example 7:Method for Assessing the Physiological Functional of the HGPRBMY26 Polypeptides In Xenopus Oocytes.”

“Example 8: Method of Assessing the Physiological Functional of the HGPRBMY26 polypeptides Using microphysiometric Assays.”

“Example 9: Method of Assessing the Physiological Functionality of the HGPRBMY26 Polypeptides Using Calc and Camp Functional Assays.”

“Example 11” Method of Screening, In Vitro Compounds That Bind to the HGPRBMY26Polypeptide

“Example 12” Method for Identifying a Potential Ligand for the HGCRBMY11Polypeptide

“Example 13” Method of Identifying Compounds That Interfere With HGPRBMY26 Polypeptide/Cellular Products Interaction

“Example 14”: Isolation of a Specific Clone From the Deposited Sample

“Example 15?”Chromosomal Mapping the Polynucleotides

“Example 16?” Bacterial Expression of a Protein

“Example 17: Purification of a Polypeptide From an Inclusion Body”

“Example 18?” Cloning and Expression of a Baculovirus Polypeptide in an Expression System

“Example 19″Expression of a Polypeptide In Mammalian Cells

“Example 20?Protein Fusions”

“Example 21: Production of an Antibody from a Polypeptide.”

“Example 22” Method of Creating C- and N-terminal Deletion Mutants Corresponding with the HGPRBMY26 polypeptide of the Present Invention

“Example 23: Method of Enhancing the Biological Activity/Functional Characteristics Of Invention Through Molecular Evolution.”

“Example 24: Method of Determining Alterations In a Gene Corresponding To a Polynucleotide.”

“Example 25” Method of Detecting Abnormally High Levels of a Polypeptide In a Biological Sample

“Example 26?Formulation”

“Example 27” Method of Treating Reduced Levels of the Polypeptide

“Example 28” Method of Treating Increased Levels Of The Polypeptide

“Example 29” Method of Treatment with Gene Therapy-Ex Vivo

“”

“Example 31” Method of Treatment using Gene Therapy?In Vivo

“Example 32?Transgenic Animals”

“Example 33?Knock-Out Animals”

“Example 34: Production of an Antibody”

“Example 35: Identification and Cloning VH and L domains of Antibodies directed against the HGPRBMY26 polypeptide”

“Example 36?Diabetic Mouse and Glucocorticoid-Impaired Wound Healing Models”

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